The Saints take on Shamrock Rovers in a crunch clash in the Tallaght Stadium this evening.
Pete Mahon's side will be fully confident following an impressive victory against Galway United on Friday.
Rovers are one of a number of clubs who are hot on the heels of St. Pat's, knowing a win for the Hoops will go top of the table, having played one more game than the Inchicore side.
St. Pat's have played Rovers on two occasions this season, with the Inchicore side taking all three points when the sides met in Tallaght back in March.
Thomas Stewart scored a brace for the Hoops when they secured a 2-1 victory in the reverse tie back in April.
Gareth Coughlan remains on the long term injury list and Neil Harney (ankle) is also out.
Both Guthrie and Lynch return from suspension while Hoops boss Michael O' Neill has a near full squad to choose from, with Dessie Baker (achillies) the only doubt for the tie.
O' Neill will have his side prepared for the game, knowing three points will put them on top of the league; “There is no doubt that this is a big game for us. Pat's have done excellent so far this season.
But we went to Inchicore earlier in the season and got an impressive win.
“This is a chance for us to go top of the league, and we'll be doing our utmost to be there at the end of the 90 minutes tomorrow.”
Match night tickets for St Pat's supporters are on sale from the club shop until 4.00pm this evening, to contact the club shop call 478 0478.