St Pats make the short trip to Tallaght Stadium for their first Dublin derby of the 2013 season as they face rivals Shamrock Rovers.
The Saints go in search of their first league win in Tallaght in three years as they aim to replicate the 2010 win which saw them defeat Michael O'Neills side 2-0 in March 2010, goals that night coming from Vinny Faherty and current Saints' full-back Ian Bermingham.
For Saints' manager Liam Buckley, the prospect of facing Shamrock Rovers in Tallaght is one which he admits will be a challenge, but one that he is relishing.
"Games between the two sides are always very tense and entertaining games, and it's one of the games fans always look to when the league fixtures are announced," Buckley told stpatsfc.com.
"There are no easy game in this league, so naturally Friday's game will be really tough, but hopefully we can produce a performance on the night and get a result for our fans on Friday who I know will be there supporting us in great numbers."
In team news, the Saints continue to be without the services of Dave Ryan who misses out again with a hand injury and Stephen Maher who serves the second of his two match suspension.
Otherwise, Buckley has a full squad available for selection.
One member of Buckley's panel in contention to play on Friday is former Shamrock Rovers midfielder Killian Brennan.
The Drogheda native, who joined the Saints from the Hoops during the winter and made his league debut last week, impressed many with his display in Buckley's midfield and Brennan told stpatsfc.com of his enjoyment of playing in a central midfield role.
"Yeah I played a little bit in the middle last year and the season before that for Bohemians.
"I'm enjoying playing in there and enjoying my football at the moment too, but we've three points on the board after one game so everyone's happy now and we'll just kick on to next week."
The stand out result between the Hoops and the Saints last season was the opening league game between the sides in Richmond Park as the Saints ran out 5-1 winners.
Brennan, who played in defence in that April 2012 clash, remembers the game well as he lined up against the Saints' two goal hero on the night, Chris Forrester.
However as Brennan pointed out, this Friday's match is another tough game for the Saints in what is a very competitive league.
"It was a big game against Drogheda last Friday, while this week we're up in Tallaght, so they're all big games.
"St Pats did quite well against Rovers last season so if we do as well as we did last year, we'll be quite happy."